Aspirin

Rofecoxib (Vioxx) and Acetaminophen effects on aspirin

Rofecoxib is a delayed release NSAIDS Rofecoxib did not affect the antiplatelet effects of aspirin This was expected because rofecoxib is a COX-2 inhibitor Acetaminophen also did not inhibit aspirins effect on platelets because it weakly binds to Cox-1 and is reversible Ibuprofen can competitively bind to COX-1 and decrease aspirins ability to be cardioprotective, therefore it is not recommended to take ibuprofen in the face of cardiac ischemia Rofecoxib and Acetaminophen do not appear to effect aspirins ability to be a cardioprotective medication [19] But wait, Vioxx (aka Rofecoxib) was taken off the market September 2004 over safety concerns by the FDA So the once safe cox-2 inhibiter maybe not safe after all