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According to the 2020 AHA Guidelines for CPR and ECC, morphine is indicated in STEMI when chest discomfort that is unresponsive to nitrates. Morphine should be used with caution in unstable angina/non-STEMI, because morphine administration was associated with increased mortality. In addition, morphine may mask symptoms of myocardial ischemia and decrease absorption of important orally administered drugs, such as antiplatelets. Currently there is no data to suggest an association between morphine and survival advantages in patients with ACS. Morphine can be administered at a dose of 2-10mg IVP pending heart rate and blood pressure. [29]
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