The B-Blocker Metoprolol can be administered for the treatment of hypertension and angina pectoris; prevention of myocardial infarction, atrial fibrillation, flutter, symptomatic treatment of hypertrophic subaortic stenosis; and to reduce increased sympathetic stimuli in acute MI. [1]
The administration of a beta-blocker such as Metoprolol following an acute MI reduced morbidity and mortality in multiple trials. Studies in the prefibrinolysis era showed a mortality benefit of 10-15% in patients treated with metoprolol and early intravenous therapy was associated with a reduction in infarct size. These observations should apply to current patients who are not treated with reperfusion or revascularization. [1] |