Polyphagia
The first reason for polyphagia is the intracellular starvation. Diabetes mellitus causes an absence or resistance to insulin action. So that means that the glucose cannot move into the cells and the cell structure is starved.
According to this Glucostat theory of feeding regulation the satiety and feeding centers regulate the feeding response. So when more glucose is utilized by the satiety center, the satiety center is activated. In diabetes due to insulin resistance or absence of insulin, glucose cannot move into the satiety center so the feeding center is chronically active.[17] | | | | | | | | |
