Allergic Reactions and Anaphylaxis

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Immunoglobulins
  • Antibodies are immunoglobulins (Ig) that bind to an antigen or foreign substance.
    • Humoral immunity involves antibodies. 
  • This binding causes a series of events that results in the lysis or phagocytosis (eating up) of the foreign invader.
  • There are five types of immunoglobulins:
  1. IgA " in mucous secretions (tears, saliva). Protects us from cold viruses
  2. IgD " on " cells
  3. IgM " best agglutinating and complement activating antibody
  4. IgE " elevated in parasitic infections and allergic reactions
  5. IgG - only class to cross the placenta.
    • Provides immunity to the fetus
    • Involved in many functions
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